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14-3-3 eta Protein by ELISA, Serum

14-3-3 ETA

Ordering Recommendation

Use as an adjunct marker in the diagnosis of rheumatoid arthritis (RA). Can be used in conjunction with rheumatoid factor (RF) and anticyclic citrullinated peptide (CCP) to enhance sensitivity. 14-3-3 eta is also used to stratify disease activity and monitor treatment effectiveness. 

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube or red top tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP standard transport tube. (Min: 0.25 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Nonserum, contaminated, heat-inactivated, severely hemolyzed, severely lipemic, or severely icteric specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month (avoid repeated freeze/thaw cycles)

Methodology

Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)

Performed

Tue

Reported

1-8 days

Reference Interval

Test Number
 Components
 Reference Interval
  14-3-3 eta Protein, Serum 0.19 ng/mL or less

Interpretive Data

The combination of serum 14-3-3 eta with rheumatoid factor (RF) and anticyclic citrullinated peptide (anti-CCP) may enhance sensitivity and demonstrates high specificity for rheumatoid arthritis (RA) diagnosis. Elevated serum 14-3-3 eta levels may be observed in both early and established RA patients, including those who are seronegative for both RF and anti-CCP antibodies. Elevated serum 14-3-3 eta concentrations are predictive of unfavorable clinical and radiological outcomes at diagnosis and posttreatment initiation. Negative or decreased levels of 14-3-3 eta from baseline correlate with diminished radiological progression and suboptimal treatment response.

Compliance Category

Analyte Specific Reagent (ASR)

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
10/21/2024
X
N/A

CPT Codes

83520

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Components

Component Test Code* Component Chart Name LOINC
3017892 14-3-3 eta Protein, Serum 75880-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • 14-3-3 eta
  • 14.3.3 eta
  • Early RA
  • joint erosion
  • Juvenile Idiopathic Arthritis
  • Psoriatic Arthritis
  • RA
  • Radiological outcomes
  • Rheumatoid Arthritis
14-3-3 eta Protein by ELISA, Serum